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Clinical Studies

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Various studies have scientifically proven that a daily intake of CARDIOSMILE significantly contributes to an improvement of cardiovascular health. Below are some interesting facts about their results:

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University of Manitoba, Canada

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This study proved the efficacy of CARDIOSMILE, a water-dispersible formulation of free plant sterols (WD-PS) versus plant sterol esters (PS esters), thus supporting the claim that there may be additional advantages in a more highly solubilized form of WD-PS in comparison with traditional PS esters in terms of controlling lipid levels.

Treatment with CARDIOSMILE showed the following results:

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All participants showed good tolerance to experimental treatments and no secondary effects were reported.

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In particular, there was a reduction (p <0.001) in the total cholesterol and LDL cholesterol levels at the end compared to control. LDL cholesterol averaged 11.7%.

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The TC to HDL-C and non-HDL-C to HDL-C ratios showed significant reductions (10.5%, 15.2%, p <0.05), during the treatment period.

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There was a decrease in TG levels (13.9%, p <0.05); i.e. it helped regulate circulating TG levels.

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A reduction of TG circulation in serum in individuals with high TG background levels. Please note that this is the first study to observe a positive effect of free plant sterol intake on TG levels.

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The 2 g/d dose of WD-PS or PS esters did not impact negatively the level of vitamins or fat-soluble carotenoids before or after adjusting the LDL-C levels, compared to control.

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There was a favorable modification of lipid profiles in blood, without altering plasma hepatic enzymes or PCR concentrations. Interestingly, compared to PS ester-enriched yogurt, the consumption of WD-PS-en- riched yogurt in hypercholesterolemic individuals not only lowered their total cholesterol and LDL cholesterol very similarly, but it also lowered their triglycerides and the TC / HDL-C ratio.

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Clinical Efficacy:

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(*) Shaghaghi M.A., Harding S.V., Jones P.J.H. (2014). Water dispersible plant sterol formulation shows improved effect on lipid profile compared to plant sterol esters. J. Funct. Foods, 6:280-9.

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University of Los Andes, Chile

This study determined the possible link between a reduction in waist size and triglycerides levels, with an increase in intestinal transit. Waist size and high triglyceride levels have been identified as two of the most relevant risk factors for cardiovascular disease, and become good indicators of the potential efficacy of plant sterols as a plausible treatment for conditions such as metabolic syndrome.

Observations were the following:

A higher proportion of individuals in the intervention group went from altered triglyceride levels to being below 150 mg / dl, showing real improvement for this parameter.

A reduction in the trend linked to waist size, particularly in women. Please note that this parameter is closely connected to cardiovascular disease.

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VLDL cholesterol decreases by 10% in the intervention group, while HDL cholesterol shows an upward trend, particularly among men.

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Triglycerides go down in both men and women, with a statistically significant difference of 12% at the end of the study.

Improved intestinal transit in women with constipation issues.

Downward trend in the total cholesterol to HDL cholesterol ratio, showing improvement in the quality of lipoproteins among patients treated with plant sterols.

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(*) Palmeiro, Y., et al. (2020). Effects of Daily Consumption of an Aqueous Dispersion of Free-Phytosterols Nanoparticles on Individuals with Metabolic Syndrome: A Randomised, Double-Blind, Placebo-Controlled Clinical Trial. Nutrients, 12(8): 2392.

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Ongoing Studies

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Part of our philosophy is to continue working on innovation, development, and scientific evidence. This is why we are permanently conducting new studies to prove the effectiveness of free plant sterols (WD-PS), and particularly of CARDIOSMILE.

This will allow us to continue to guarantee its contribution to cardiovascular health, which is aligned with our purpose of accompanying people in the adoption of a lasting healthy lifestyle.

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University of Toronto, Canada.

Completion date: December 2022.

The purpose of this study is to determine whether a dietary portfolio of cholesterol-lowering foods (viscous fibers, soy protein, plant sterols and nuts) further enhanced by increased levels of monounsaturated fatty acids (MUFA) and low glycemic index foods; together with a structured exercise program reduce the progression of carotid and coronary atheromatous lesions, Low density lipoprotein-cholesterol (LDL-C), and blood pressure, while reducing the number of individuals requiring statins.

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Do you want more information about CARDIOSMILE product technology & applications, clinical studies (research agreements or support in the formulation or development of a clinical study of interest), or how to be our business partner in your country to co-create the new health paradigm? Then send us a message and we’ll contact you as soon as possible.

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