Cardiosmile Plant Sterols

What are plant sterols?

They are natural substances present in foods such as legumes, fruits, and vegetables. You could say that they are like the “cholesterol” of vegetables, because their molecular structure is very similar to that of cholesterol, and just like it, they perform a structural function in the organisms that contain them.

What makes plant sterols so beneficial is that their components block the absorption of both endogenous cholesterol (produced by your liver) and exogenous cholesterol (coming from animal source foods) in your intestine. That is how they help control cholesterol levels in your body and contribute to the prevention of cardiovascular disease and other conditions caused by metabolic deviations.

Various meta-analyses report that a daily intake of 2 grams of plant sterols lowers cholesterol by 10% to 15% (Demonty, 2009; AbuMweis, 2008; Ras, 2013). Suggested cholesterol-lowering mechanisms are (De Smet, 2012): inhibiting cholesterol absorption in the enterocyte, inhibiting its re-esterification and thus avoiding its incorporation into lipoproteins and expelling unesterified cholesterol back to the intestinal lumen.

Plant sterols

Cardiosmile, a Novel Nano-dispersion

Due to the chemical structure and the low solubility of plant sterols, they must be formulated correctly in order to obtain optimum health benefits. Traditionally, this has been done by esterification with fatty acids of vegetable origin which allow higher solubility in fats, and they are later incorporated into margarine, milk, or yogurt.

After several years of research, NUTRARTIS created CARDIOSMILE, the first product to incorporate 2 grams of fat-free plant sterols. This is done by reducing plant sterol particles to a submicron size (400 nm average), which enable particles to remain dispersed in water in a stable manner with minimum use of surfactants.

Plant Sterols nanodispersion
Nanodispersion under microscope

With this novel solution not only it is possible to quickly mix CARDIOSMILE into any type of food, but most importantly, its clinical effectiveness in lowering cholesterol levels can be guaranteed. Additionally, our product:

It is cholesterol free.

It is calorie free.

It has no trans or saturated fats.

It does not need refrigeration.

It can be mixed into any food base without changing its taste or smell.

A clinical study that compared CARDIOSMILE to traditional plant sterol esters showed an effective reduction in LDL cholesterol after one week, which proves the clinical effectiveness hypothesis. And surprisingly, unlike other plant sterols CARDIOSMILE produced a significant decrease in patients’ triglyceride levels over the same period of intervention of one month*.

(*) Amir Shaghaghi, J.Funct.Food 2014, 280-289

Cardiosmile package
Clinically Tested


CARDIOSMILE‘s manufacturing process was developed over the course of ten years. Its unique patented process combines a set of never-seen-before process conditions, which is why our plant was designed and built in-house, working with industry partners to comply with the most stringent GMP guidelines. The process itself consists of very few unitary steps, chiefly creating a lipid-in-water emulsion, to then crystallize the lipid particles to yield a stable sub-micron dispersion with a high sterol content. Our experts jointly accumulate several decades of experience, making our process virtually irreplicable.

Currently, our one-of-a-kind plant located in the heart of Chile has the capability to manufacture 1.000.000 Cardiosmile units per year, although our vision includes plans to create capacity in other countries as demand requires.


In order to certify CARDIOSMILE’s quality and its compliance with regulations from different countries. NUTRARTIS has ensured that our product is certified as follows:

Our operations follow the principles of Good Manufacturing Practices according to United States’ NSF (US 21 CFR 110).

Do you want to know more?

Do you want more information about CARDIOSMILE product technology & applications, clinical studies (research agreements or support in the formulation or development of a clinical study of interest), or how to be our business partner in your country to co-create the new health paradigm? Then send us a message and we'll contact you as soon as possible.